CAS RN: 75-44-5

Range of Toxicity

A) TOXIC DOSE: ODOR PERCEPTION: Phosgene concentration of greater than 0.125 ppm. RECOGNITION OF ODOR: Phosgene concentration of greater than 1.5 ppm. IRRITANT EFFECTS: Phosgene concentration of greater than 3 ppm, irritation of the eyes, nose, throat, and upper respiratory tract can occur. Total dose (concentration in ppm multiplied by time of exposure in minutes) determines the risk of pulmonary edema. PULMONARY EFFECTS: An inhalation dose of less than 50 ppm-min: unlikely to produce any pulmonary effects; 50 to 150 ppm-min: subclinical pulmonary effects, edema unlikely; 150 ppm-min or above: pulmonary edema probable; 300 ppm-min or above: life-threatening pulmonary edema is likely. The lowest published lethal concentration for a human is 50 ppm for 5 minutes. The NIOSH TLV TWA is 0.1 ppm and 2 ppm is considered immediately dangerous to life and health (IDLH).
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