Azinphosmethyl

A) A toxic dose has not been established. The World Health Organization (WHO) has classified azinophos-methyl as pesticide class 1B (highly hazardous). Organophosphates are absorbed across the lung, mucous membranes (including gut), and skin. Poisoning depends upon inherent toxicity, dosage, rate of absorption, rate of metabolic breakdown, and prior exposure to other cholinesterase inhibitors.
B) Azinphos-methyl did not cause significant cholinesterase depression or cause clinical effects when administered to human volunteers at 4 to 20 mg/day for 30 days.